Thromboxane A2 Moderates Permeability after Limb Ischemia
نویسندگان
چکیده
منابع مشابه
Thromboxane A2 mediates increased pulmonary microvascular permeability following limb ischemia.
Lower torso ischemia and reperfusion lead to respiratory dysfunction characterized by pulmonary hypertension and increased lung microvascular permeability. This is associated with lung leukosequestration and thromboxane (TX) generation. This study tests the role of elevated TX levels following muscle ischemia in mediating remote lung injury. Anesthetized sheep prepared with chronic lung lymph f...
متن کاملThromboxane A2 Mediates Increased Pulmonary Microvascular PermeabUity Following Limb Ischemia
Lower torso ischemia and reperfusion lead to respiratory dysfunction characterized by pulmonary hypertension and increased lung microvascular permeability. This is associated with lung leukosequestration and thromboxane (TX) generation. This study tests the role of elevated TX levels following musde ischemia in mediating remote lung injury. Anesthetized sheep prepared with chronic lung lymph fi...
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This study examines the hypothesis that intestinal reperfusion (IR)-induced pulmonary thromboxane A2 (TxA2) release increases local microvascular permeability and induces pulmonary vasoconstriction. Sprague-Dawley rats underwent 120 min of intestinal ischemia and 60 min of IR. Sham-operated animals (Sham) served as controls. After IR or Sham, the pulmonary vessels were cannulated, and the lungs...
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In monkeys with early and advanced atherosclerosis, we examined responses to the three major vasoactive agonists that are released when platelets aggregate. Measurements were obtained in normal cynomolgus monkeys and in monkeys fed an atherogenic diet for 4+1, 9±1, and 19±1 months (mean± SEM). Morphometry of femoral and iliac arteries indicated that 4 months of atherogenic diet produced only sl...
متن کاملThromboxane Modulates Endothelial Permeability
The study tests the role of thromboxane in modulating microvascular permeability in vitro. Cultured monolayers of bovine aortic endothelial cells were challenged with the thromboxane (Tx) mimic U46619. This led to disassembly of actin microfilaments, cell rounding, border retraction and interendotheHal gap formation. Pretreatment with the Tx receptor antagonist SQ 29,548 prevented the Tx mimic-...
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ژورنال
عنوان ژورنال: Annals of Surgery
سال: 1985
ISSN: 0003-4932
DOI: 10.1097/00000658-198511000-00017